Regulation of vascular smooth muscle cell function by adenylyl cyclase isoforms
نویسندگان
چکیده
منابع مشابه
Regulation of Vascular Smooth Muscle Cell Function by Mechanical Strain
Although smooth muscle cells participate in the remodeling associated with atherosclerosis and other vascular diseases, the mechanisms by which these cells interact with their mechanical environment are incompletely characterized. This thesis serves to elucidate the capacity of smooth muscle cells to modulate their matrix and respond to mechanical loading. Because integrins mediate many cell-ma...
متن کاملAdenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization.
Compartmentation of cAMP signaling been demonstrated to be attributable to the structural association of protein kinase A (PKA) (via association with A-kinase anchoring proteins [AKAPs]) with phosphodiesterase and AKAP-dependent effector molecules. However, other mechanisms contributing to compartmentalization have not been rigorously explored, including the possibility that different isoforms ...
متن کاملModulation of G-protein expression and adenylyl cyclase signaling by high glucose in vascular smooth muscle.
OBJECTIVE We have recently shown a decreased expression of Gialpha proteins and associated functions in aorta from short term (5 days) streptozotocin-induced diabetic rats. Since hyperglycemia is one of the underlying causes of diabetes-induced cardiovascular complications, it was of interest to examine if hyperglycemia may play a direct role in down regulating the expression of Gialpha in vasc...
متن کاملHuman airway smooth muscle expresses 7 isoforms of adenylyl cyclase: a dominant role for isoform V.
Adenylyl cyclases are a nine-member family of differentially regulated enzymes responsible for the synthesis of cAMP. cAMP is an important second messenger that contributes to the regulation of airway smooth muscle tone. However, little is known regarding the expression and regulation of adenylyl cyclase isoforms in airway smooth muscle cells. Nondegenerate specific primers were designed for al...
متن کاملDecreased adenylyl cyclase protein and function in airway smooth muscle by chronic carbachol pretreatment.
Cellular levels of cAMP are an important determinant of airway smooth muscle tone. We have previously shown that chronic (18 h) but not acute (30 min or 2 h) pretreatment with the muscarinic receptor agonist carbachol resulted in decreased adenylyl cyclase activity in response to GTP, isoproterenol, or forskolin via a pathway blocked by the protein kinase C inhibitor staurosporine. The present ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a1117-b